Mechanisms for enzymatic cleavage of the N-glycosidic bond in DNA
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چکیده
منابع مشابه
Mechanisms for enzymatic cleavage of the N-glycosidic bond in DNA.
DNA glycosylases remove damaged or enzymatically modified nucleobases from DNA, thereby initiating the base excision repair (BER) pathway, which is found in all forms of life. These ubiquitous enzymes promote genomic integrity by initiating repair of mutagenic and/or cytotoxic lesions that arise continuously due to alkylation, deamination, or oxidation of the normal bases in DNA. Glycosylases a...
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ژورنال
عنوان ژورنال: Org. Biomol. Chem.
سال: 2014
ISSN: 1477-0520,1477-0539
DOI: 10.1039/c4ob01063a